The UIC BIRCWH team is excited to announce the addition a new BIRCWH scholar, Dr. Kirstie Danielson. Dr. Danielson is an Assistant Professor in the Division of Transplant Surgery, and a departmental affiliate in the Division of Epidemiology & Biostatistics at UIC. She received her PhD in Population Health, with a focus in Epidemiology, from the University of Wisconsin-Madison; and subsequently completed postdoctoral training in Endocrinology at the University of Chicago and Epidemiology & Biostatistics at UIC. Building upon her research on interrelationships between diabetes, bone, and sex hormones in women, her goal is to establish an independent research program in diabetes epidemiology and women’s health at UIC, initially focused on two interrelated and synergistic tracks: the bidirectional association between diabetes and bone and sex-based differences in islet transplantation. For the first aim, Dr. Danielson will describe the prevalence and etiology of sex-based differences in bone fragility due to type 1 (insulin-dependent) diabetes; and following islet (insulin-producing cells) transplantation to cure type 1 diabetes. In light of recent experimental evidence demonstrating lack of the bone protein osteocalcin leads to diabetes in mice, she will determine whether bone metabolism is prospectively associated with the disease course in humans with type 1 diabetes and islet transplantation outcomes; and if there are sex-based differences. For the second aim, Dr. Danielson will explore whether there are sex-based differences in islet function and clinical outcomes following islet transplant to cure type 1 diabetes. Islets grow during pregnancy and estrogen enhances their function. However, there have been no systematic comparisons of islet function in vitro and following transplant by sex of donor or recipient.
Dr. Danielson focuses on chronic diseases because they encompass major public health challenges, and diabetes and bone fragility are examples of chronic diseases with differences in prevalence and outcomes by sex. Elucidating potential sex-based differences is critical for individualized medicine in preventing, treating, and curing chronic diseases.
